6533b859fe1ef96bd12b788a
RESEARCH PRODUCT
Cladosporinone, a new viriditoxin derivative from the hypersaline lake derived fungus Cladosporium cladosporioides
Georgios DaletosChang-yun WangPeter ProkschWenhan LinWerner E. G. M�llerRaha OrfaliYang LiuYang LiuTibor Kurtánsubject
Circular dichroismMagnetic Resonance SpectroscopyLymphomaAntiparasiticmedicine.drug_classStereochemistryCladosporium cladosporioidesAntineoplastic AgentsNaphtholsBiologymedicine.disease_cause01 natural sciencesInhibitory Concentration 50Micechemistry.chemical_compoundTermészettudományokBiosynthesisCell Line TumorDrug DiscoverymedicineAnimalsBioassayKémiai tudományokCytotoxicityPharmacologyBacteria010405 organic chemistryCircular DichroismPathogenic bacteriaHypersaline lakebiology.organism_classificationAnti-Bacterial Agents0104 chemical sciencesLakes010404 medicinal & biomolecular chemistrychemistryEgyptCladosporiumdescription
A new cytotoxic viriditoxin derivative, cladosporinone (1), along with the known viriditoxin (2) and two viriditoxin derivatives (3 and 4) were obtained from the fungus C ladosporium cladosporioides isolated from the sediment of a hypersaline lake in Egypt. The structure of the new compound (1) was determined by 1D and 2D NMR measurements as well as by high-resolution ESIMS and electronic circular dichroism spectroscopy. All isolated compounds were studied for their cytotoxicity against the murine lymphoma cell line L5187Y and for their antibiotic activity against several pathogenic bacteria. Viriditoxin (2) was the most active compound in both bioassays. Compound 1 also exhibited strong cytotoxicity against the murine lymphoma cell line L5187Y with an IC50 value of 0.88 μm, whereas its antibiotic activity was weak.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2015-11-19 | The Journal of Antibiotics |