6533b859fe1ef96bd12b79bb

RESEARCH PRODUCT

A survey on tubulin and arginine methyltransferase families sheds light on p. lividus embryo as model system for antiproliferative drug development

Caterina CasanoSalvatore CostaFabrizio GianguzzaAldo NicosiaMaria Antonietta Ragusa

subject

Sea urchinPRMTSettore BIO/11 - Biologia MolecolareDrug actionmacromolecular substancesBiologyCatalysisCatalysilcsh:ChemistryInorganic ChemistryMicrotubuleArginine methylationTubulinbiology.animalGene familyPhysical and Theoretical ChemistrySea urchinlcsh:QH301-705.5Molecular BiologySpectroscopyEchinodermechinodermsOrganic ChemistryEmbryoComputer Science Applications1707 Computer Vision and Pattern RecognitionGeneral MedicineMethylationComputer Science ApplicationsCell biologyTubulinDrug developmentlcsh:Biology (General)lcsh:QD1-999embryonic structuresbiology.proteinPost-translational modification

description

Tubulins and microtubules (MTs) represent targets for taxane-based chemotherapy. To date, several lines of evidence suggest that effectiveness of compounds binding tubulin often relies on different post-translational modifications on tubulins. Among them, methylation was recently associated to drug resistance mechanisms impairing taxanes binding. The sea urchin is recognized as a research model in several fields including fertilization, embryo development and toxicology. To date, some &alpha

yearjournalcountryeditionlanguage
2019-04-01
10.3390/ijms20092136http://hdl.handle.net/10447/358148