6533b859fe1ef96bd12b79bc

RESEARCH PRODUCT

Search for potential Angiotensin Converting Enzyme (ACE)-inhibitors from plants

Hildebert WagnerU. FranckLacaille-dubois

subject

Musanga cecropioidesPharmaceutical ScienceAngiotensin-Converting Enzyme InhibitorsCrataegus oxyacanthaCleavage (embryo)AnthocyaninsDiglycineDrug DiscoveryHumansProanthocyanidinsFlavonoidsPharmacologychemistry.chemical_classificationPlants MedicinalbiologyPlant ExtractsChemistryAngiotensin-converting enzymebiology.organism_classificationIn vitroEnzymeComplementary and alternative medicineBiochemistryProanthocyanidinbiology.proteinMolecular Medicine

description

MeOH extracts, fractions and pure substances from Musanga cecropioides, Cecropia species and Crataegus oxyacantha /C. monogyna were screened by using an in vitro bio-assay based on the inhibition of Angiotensin Converting Enzyme (ACE), as measured from the enzymatic cleavage of the chromophore-fluorophore-labelled substrate dansyltriglycine into dansylglycine and diglycine. Phenolic acids showed no significant ACE-inhibition whereas flavonoids and proanthocyanidins demonstrated inhibitory activity at 0.33 mg/ml using this test system.

yearjournalcountryeditionlanguage
2001-04-09Phytomedicine
https://doi.org/10.1078/0944-7113-00003