6533b859fe1ef96bd12b7f38

RESEARCH PRODUCT

Acetogenins from Annona glabra seeds

José R. TormoM. Carmen Zafra-poloRaúl AragónM. Amparo BlázquezTeresa GallardoDiego Cortes

subject

chemistry.chemical_classificationbiologyStereochemistryAnnonacinRespiratory chainPlant ScienceGeneral MedicineHorticultureCorossolonebiology.organism_classificationBiochemistrychemistry.chemical_compoundMitochondrial respiratory chainchemistryAnnona glabraAnnonaceaeAcetogeninMolecular BiologyLactone

description

Abstract From the cytotoxic ethanol extract of Annona glabra seeds, a new mono-tetrahydrofuranic (mono-THF) acetogenin, glabranin, as well as pair of 22-epimer bis-THF acetogenins, were isolated by semipreparative HPLC. Four known mono-THF acetogenins with an identical threo/trans/threo relative configuration, annonacin, annonacinone, corossolin and corossolone, were found to be potent inhibitors of complex I of the mitochondrial respiratory chain.

yearjournalcountryeditionlanguage
1998-03-01Phytochemistry
https://doi.org/10.1016/s0031-9422(97)00780-2