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RESEARCH PRODUCT
Alternative Methods to Animal Testing in Safety Evaluation of Cosmetic Products
Virginia MerinoM. MerinoAmparo NácherOctavio Díez-salessubject
0301 basic medicineAlternative methodsbusiness.industrySkin sensitizationDevelopmental toxicityBioinformaticsmedicine.disease_cause03 medical and health sciences030104 developmental biology0302 clinical medicineToxicityMedicineIrritationAnimal testingbusinessPhototoxicityAcute toxicity testing030217 neurology & neurosurgerydescription
Abstract This chapter reviews alternative methods recommended for animal testing in various toxicological areas. An alternative model to achieve complete animal replacement for acute toxicity testing is not possible. Skin corrosion/irritation alternative methods have been validated and accepted. For eye irritation testing, no single method is able to replace the Draize rabbit eye test. Skin sensitization methods imply refinement and reduction of numbers of animals. An in vitro dermal absorption test could be an alternative to in vivo testing. There are no generally accepted alternative methods to replace the usual repeated-dose toxicity in vivo assays. To determine the genotoxic and mutagenic potential of a compound a battery of in vitro tests may be used. Two alternative methods may provide information on possible carcinogenic effects. Acute phototoxicity can be assayed with in vitro tests, and for reproductive and developmental toxicity three embryotoxicity tests have been formally validated (by ECVAM). Complete animal replacement will represent a scientific and technical challenge.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2018-01-01 |