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RESEARCH PRODUCT
Sterols in Infant Formulas: A Bioaccessibility Study.
Guadalupe Garcia-llatasLuis Manuel Sanchez-silesMaría Jesús LagardaIslam J. A. Hamdansubject
0301 basic medicineCampesterolBrassicasterol03 medical and health scienceschemistry.chemical_compound0404 agricultural biotechnologyDesmosterolHumansFood science030109 nutrition & dieteticsStigmasterolCholesterolFatty AcidsPhytosterols04 agricultural and veterinary sciencesGeneral Chemistry040401 food scienceSterolInfant FormulaSterolsVegetable oilchemistryInfant formulalipids (amino acids peptides and proteins)DigestionGeneral Agricultural and Biological Sciencesdescription
The design of infant formulas (IFs) seeks to resemble human milk (HM) composition and functionality. The fat sources used usually comprise vegetable oil blends to mimic the fatty acid composition of HM and introduce changes in the animal/plant sterol ratio. In contrast, the use of milk fat globule membrane (MFGM)-rich ingredients could improve this aspect by increasing the ratio. The present study evaluates the bioaccessibility (BA) of sterols (cholesterol, desmosterol, brassicasterol, campesterol, stigmasterol, and β-sitosterol) in three IFs (with or without MFGM) using an in vitro digestion method simulating infant conditions. Analytical parameters confirmed the suitability of the method for all of these sterols. Results showed the presence of MFGM to increase cholesterol content (6-7 vs 2 mg/100 mL), this being the most bioaccessible sterol in the IFs. Although the BA of cholesterol was reduced in MFGM-enriched IF (65.6-80.4% vs 99.7%), the intake of bioaccessible cholesterol from these IFs was higher.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2018-01-26 | Journal of agricultural and food chemistry |