Plazmas miRNS kā multiplās sklerozes biomarķieri

6533b859fe1ef96bd12b8601

RESEARCH PRODUCT

Plazmas miRNS kā multiplās sklerozes biomarķieri

Anastasija Rudņickiha

subject

biomarkers Bioloģija multiple sclerosis cell-free miRNAs miR-484

description

Vairākos pētījumos ir atklātas miRNS, tajā skaitā cirkulējošas miRNS, kuru daudzums ir izmainīts multiplā sklerozē. miRNS kā jaunu biomarķieru izpēte šai slimībai varētu palīdzēt diagnosticēt un prognozēt tās attīstību agrīnā stadijā. Šajā pētījumā ir prezentēti mūsu dati par dažām miRNS, kas tikadetektētas MS pacientu asins plazmā, kā izmainītas. Mēs salīdzinājām miRNS ekspresijas līmeņus MS un tās apakštipos ar veselo kontroli, lai atrastu potenciālās miRNS, kas var tikt izmantotas, kā MS biomarķieri. Galvenais mērķis bija validēt sekvenēšanas rezultātā atlasītās miRNS, kuru daudzums bija izmainīts MS pacientu asins plazmā neatkarīgā pacientu kopā. miRNS 484, kuras daudzums bija visvairāk izmainīts saskaņā ar sekvenēšanas datiem, tika validēta ar qPCR neatkarīgā MS pacientu kopā. Tas norāda uz šīs miRNS potenciālu kā MS diagnostiskais biomarķieris.

year	journal	country	edition	language
2018-01-01

https://dspace.lu.lv/dspace/handle/7/38622

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