6533b85afe1ef96bd12b89f2

RESEARCH PRODUCT

Influence of sodium lauryl sulphate on the in vitro percutaneous absorption of compounds with different lipophilicity

M. J. MorantOctavio Díez-salesM Herráez-domı́nguezA. LópezJ. Borrás-blasco

subject

Chromatographyintegumentary systemPermeability (electromagnetism)ChemistrySodium lauryl sulphateLipophilicityPercutaneous absorptionmedicinePharmaceutical ScienceSalicylamideIn vitroPentoxifyllinemedicine.drug

description

Abstract The effects of sodium lauryl sulphate (SLS) at different concentrations on the “in vitro” percutaneous absorption of a number of compounds (5-fluorouracil, antipyrine, pentoxifylline, salicylamide, 4-ethylaniline, 4-n-butylaniline and indomethacin) with a wide range of lipophilicity values (log POCT from −0.95 to 4.42) through rat skin were analysed. After pretreatment of the skin with SLS (1% and 5%, w/w) the permeability coefficients increased only for compounds having a log POCT

yearjournalcountryeditionlanguage
1997-01-01European Journal of Pharmaceutical Sciences
https://doi.org/10.1016/s0928-0987(96)00184-4