6533b85afe1ef96bd12b8b4c

RESEARCH PRODUCT

Ultrastructural evidence of collagenolytic activity in ductal infiltrating carcinoma of the human breast

Serafina SciarrinoClaudio LuparelloRosario SchillaciIda Pucci-minafra

subject

Cancer ResearchProteasesPathologymedicine.medical_specialtyMammary glandBreast Neoplasmsmacromolecular substancesBiologyLesionStromamedicineHumansTrypsinFragmentation (cell biology)AgedPancreatic ElastaseMiddle AgedIn vitroMicroscopy ElectronCarcinoma Intraductal NoninfiltratingMicrobial Collagenasemedicine.anatomical_structureOncologyCollagenaseUltrastructureFemaleCollagenmedicine.symptommedicine.drug

description

The stroma of ductal infiltrating carcinoma of the human breast shows characteristic and localized areas of collagen rarefaction and fragmentation. This finding has been correlated with a peculiar type of fibrillar damage, observed in a small percentage of collagen fibrils isolated in the native state from the tumour stroma. The same pattern of lesion has been reproduced in vitro by human collagenase digestion on reconstituted fibrils. No effect has been detected by other nonspecific proteases in the same system.

yearjournalcountryeditionlanguage
1987-05-15
http://www.scopus.com/inward/record.url?eid=2-s2.0-0023194407&partnerID=MN8TOARS