6533b85afe1ef96bd12b8ba5
RESEARCH PRODUCT
The significance of serum soluble IL-2 receptor as a marker for active visceral leishmaniasis in Sicilian patients
Renato MaltaR. D'agostinoG. ReinaS. MansuetoGiustina VitaleG. GambinoC. MocciaroMaria DieliEnrico Cillarisubject
Interleukin 2ImmunologyLeishmania donovaniBiologyPeripheral blood mononuclear cellInterferon-gammaAntigenmedicineAnimalsHumansImmunology and AllergyIL-2 receptorSicilyPhytohaemagglutininReceptors Interleukin-2Leishmaniasismedicine.diseasebiology.organism_classificationVisceral leishmaniasisSolubilityImmunologyLeukocytes Mononuclearbiology.proteinInterleukin-2Leishmaniasis VisceralLeishmania donovaniResearch Articlemedicine.drugdescription
SUMMARY Sera from nine Sicilian patients with confirmed visceral leishmaniasis (Leishmania donovani infantum; VL), at the moment of the diagnosis, during the course of the disease and after clinical recovery, were analysed for the concentration of soluble IL-2 receptor (sIL-2R). The results show that sIL-2R is a marker of disease activity, since it is in high concentration at the beginning of infection and returns to the normal range following successful chemotherapy. At the same time of serum analysis for sIL-2R, peripheral blood mononuclear cells (PBMC) of VL patients were stimulated with phytohaemagglutinin (PHA) or antigen and supernatant tested for IL-2 and interferon-gamma (IFN-γ) production. Data demonstrate that there is an inverse relation between concentration of IL-2 and IFN-γ in the supernatants and sIL-2R secretion in the sera.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1992-11-01 | Clinical and Experimental Immunology |