6533b85afe1ef96bd12b8c50
RESEARCH PRODUCT
RADHA - a new male germ line-specific chromosomal protein of Drosophila
Anna AkhmanovaHarry R. HarhangiChrista HeytingXiaoping SunYa Xian WangWolfgang HennigKoos Miedemasubject
MaleLeucine zipperTranscription GeneticMolecular Sequence DataBiologyLaboratorium voor ErfelijkheidsleerMeiosisSpermatocytesTestisGeneticsMelanogasterAnimalsDrosophila ProteinsLife ScienceAmino Acid SequenceGeneGenetics (clinical)GeneticsPolytene chromosomeBase SequenceDNAbiology.organism_classificationChromatinDrosophila melanogasterInsect ProteinsLaboratory of GeneticsDrosophila melanogasterEPSDrosophila Proteindescription
A new chromosomal protein - RADHA - of Drosophila is described that is specific for the male germ line. It is encoded by a single-copy gene, located in the region 96C-D of D. melanogaster polytene chromosomes. Transcription of the radha gene is restricted to the primary spermatocyte stage. The protein initially accumulates in some of the Y-chromosomal lampbrush loops. After meiosis it is found in the nuclei of spermatids and might be involved in chromatin rearrangement processes in the male germ line. RADHA is a basic protein with a C-terminal leucine zipper region and several segments capable of forming coiled-coil structures.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1999-01-01 |