6533b85afe1ef96bd12b8e04
RESEARCH PRODUCT
Effects of iontophoretic 5-hydroxytryptamine on the unitary discharge frequency of caudate nucleus neurons in the rat
A. PostorinoR. CortimigliaS. VetroM. T. ZagamiV. La Gruttasubject
NeuronsLong lastingSerotoninIontophoresisPhysiologyChemistryElectric ConductivityCaudate nucleusInhibitory postsynaptic potentialSerotonergicBiochemistryRatsAnimalsCaudate NucleusNeurosciencedescription
AbstractSummaryMicroiontophoretic application of 5-hydroxytryptamine (5-HT) on rat caudate nucleus neurons has both facilitatory and inhibitory effects on the discharge frequency of the neurons; in many cases 5-HT has a two-phase action. An analysis was made of the behaviour of facilitatory and inhibitory responses in time considering the mean firing rate variations during and after 5-HT iontophoretic release. Six types of responses have been described : A : short lasting excitation, B : long lasting excitation, C : short lasting inhibition, D : delayed-onset inhibition, E : inhibition followed by excitation, F : excitation followed by inhibition. Also no topographic localization could be made of neurons sensitive to application of 5-HT, as could be expected from data relative to the distribution of the serotoninergic terminals of the caudate nucleus. Lastly, it is interesting to consider the good percentage of neurons facilitated by the application of 5-HT, a finding that might give new insight into the ...
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1980-05-01 | Archives Internationales de Physiologie et de Biochimie |