6533b85afe1ef96bd12b8e93

RESEARCH PRODUCT

Species differences, influence of dose and application on biotransformation of phenol in fish.

R. Nagel

subject

TroutHealth Toxicology and MutagenesisToxicologyBiochemistrychemistry.chemical_compoundLeuciscusBiotransformationPhenolsSpecies SpecificityGoldfishPhenolAnimalsFood sciencePhenolsBiotransformationPharmacologybiologyDose-Response Relationship DrugFishesWaterGeneral MedicineMetabolismbiology.organism_classificationTroutchemistryBiochemistryFoodRainbow troutGlucuronideInjections Intraperitoneal

description

1. The metabolism of phenol in goldfish (Carassius auratus), rainbow trout (Salmo gairdneri) and goldenorfe ide (Leuciscus ideus melanotus) was compared. All three species produced phenyl sulphate, quinol sulphate and phenyl glucuronide. 2. The dose dependence of metabolism of phenol in goldfish was investigated. When the concn. of phenol was increased from 0.2 to 2 mg/l medium, that glucuronylated increased from 7 to 16% and that sulphated decreased from 63 to 47%. 3. The influence of mode of exposure on metabolism of phenol in goldfish was examined. Dietary exposure and uptake from medium was compared with i.p. injection. There was less metabolism in the order: dietary exposure greater than uptake from medium greater than injection.

yearjournalcountryeditionlanguage
1983-02-01Xenobiotica; the fate of foreign compounds in biological systems
10.3109/00498258309052243https://pubmed.ncbi.nlm.nih.gov/6880237