ChemInform Abstract: A New Strategy for the Synthesis of Fluorinated 3,4-Dihydropyrimidinones.

6533b85afe1ef96bd12b944e

RESEARCH PRODUCT

ChemInform Abstract: A New Strategy for the Synthesis of Fluorinated 3,4-Dihydropyrimidinones.

Silvia Catalan Jose Luis Acena Carlos Del Pozo Santos Fustero

subject

chemistry.chemical_classification Addition reaction Nucleophilic addition Reaction sequence Tandem chemistry Thio-General Medicine Combinatorial chemistry Alkyl

description

A new family of 3,4-dihydropyrimidinones (DHPMs) bearing fluorinated substituents at C6 have been prepared from gem-difluorinated nitriles, alkyl 3-butenoates and iso(thio)cyanates. This novel Biginelli-type process relies on the γ-addition of the ester-derived enolate to fluorinated nitriles. A tandem nucleophilic addition aza-Michael reaction sequence completes the synthetic process.

year	journal	country	edition	language
2010-05-04	ChemInform

https://doi.org/10.1002/chin.201018158

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