6533b85afe1ef96bd12b985d
RESEARCH PRODUCT
The parkin gene is not a major susceptibility locus for typical late-onset Parkinson's disease
Carmine TomainoR. L. OliveriA. EpifanioPatrizia SpadaforaMario ZappiaGiuseppe NicolettiGrazia AnnesiAldo QuattroneDomenico BoscoDemetrio MessinaLetterio MorganteG. ManobiancaAngela Aurora PasquaFerdinanda AnnesiGiovanni SavettieriGiancarlo Logroscinosubject
Malemedicine.medical_specialtyNeurologyParkinson's diseaseUbiquitin-Protein LigasesDNA Mutational AnalysisMolecular Sequence DataLate onsetGenes RecessiveDermatologyDiseaseParkinPathogenesisLigasesParkinsonian DisordersmedicineHumansPoint MutationGenetic Predisposition to DiseaseGenetic TestingAge of OnsetAgedGeneticsbusiness.industryGeneral MedicineExonsParkin geneMiddle Agedmedicine.diseasenervous system diseasesPsychiatry and Mental healthSusceptibility locusChromosomes Human Pair 6FemaleNeurology (clinical)businessdescription
We investigated the parkin gene in 118 patients with typical Parkinson's disease (PD), i. e. in patients who had an onset of PD after the age of 45 years. The study group included 95 subjects with sporadic PD and 23 subjects from 18 families with autosomal recessive PD. No pathogenetic mutations in the parkin gene were detected either in familial or in sporadic patients. Our findings indicate that the parkin gene is not involved in the pathogenesis of classic late-onset PD.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2001-01-01 |