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RESEARCH PRODUCT
A Concise, Asymmetric Synthesis of Tetramic Acid Derivatives
Juan F. Sanz-cerveraAntonio SimónCarmen Ramírez De ArellanoMarta Garcia De La TorreSantos FusteroAnd Julio Pierasubject
Turn (biochemistry)chemistry.chemical_compoundchemistryStereochemistryOrganic ChemistryEnantioselective synthesisTetramic acidPhysical and Theoretical ChemistryBiochemistryCarbonyldiimidazoledescription
[reaction: see text] A simple, asymmetric synthesis of tetramic acid derivatives is described in this paper. The key step is a carbonyl transfer from carbonyldiimidazole (CDI) to alpha-diimines (I) to form N-alkyl-4-alkylamino-5-methylenepyrrol-2-ones (II). In turn, these compounds can be easily transformed into tetramic acid derivatives (III) in two additional steps.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2002-09-19 | Organic Letters |