Resolution of inherently chiral resorcarene derivatives by enantioselective HPLC

6533b85afe1ef96bd12b9e66

RESEARCH PRODUCT

Resolution of inherently chiral resorcarene derivatives by enantioselective HPLC

Volker Bo¨hmer Grazia Principato Christian Schmidt Salvatore Caccamese

subject

Chromatography Resolution (mass spectrometry)Elution Chemistry Organic Chemistry Drug Discovery Narrow range Chiralpak AD Enantiomer Resorcinarene Biochemistry Enantioselective hplc High-performance liquid chromatography

description

Abstract The HPLC enantiomeric resolution of five inherently chiral tetrabenzoxazine derivatives of resorcarenes has been achieved by HPLC using Whelk-Ol and in one case Chiralpak AD as stationary phases. Enantiomeric separation was only observed in a very narrow range of mobile phase compositions. On-column enantiomeric interconversion of a racemic compound with a typical plateau-like elution profile was observed using a Chiralpak AD column

year	journal	country	edition	language
1999-08-01	Tetrahedron Letters

https://doi.org/10.1016/s0040-4039(99)01175-2

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