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RESEARCH PRODUCT

Natriuretic peptide system expression in murine and human submandibular salivary glands: a study of the spatial localisation of ANB, BNP, CNP and their receptors

Abdo JurjusIsabelle MiletichAlessandro GulinoSimita AmayoAda Maria FlorenaAraz AhmedAngelo LeoneAngelo LeoneWalter ArancioBeatrice Belmonte

subject

MaleSettore BIO/17 - Istologia0301 basic medicinemedicine.medical_specialtyHistologyReceptors PeptidePhysiologymedicine.drug_classAtrial natriuretic peptide ANPNatriuretic peptide receptor B NPRBMice03 medical and health sciences0302 clinical medicineAtrial natriuretic peptideInternal medicineNatriuretic Peptide BrainmedicineNatriuretic peptideAnimalsHumansAutonomic nervous systemB-type natriuretic peptide BNPNatriuretic peptide receptor C NPRCAutocrine signallingReceptorSalivary glandSubmandibular glandSalivary glandC-type natriuretic peptide CNPChemistryNatriuretic Peptide C-TypeCell BiologyGeneral MedicineNatriuretic peptide receptor A NPRABrain natriuretic peptideSubmandibular glandNeoplasm Proteins030104 developmental biologymedicine.anatomical_structureEndocrinologyOral squamous cell carcinoma030220 oncology & carcinogenesisCarcinoma Squamous CellFemaleMouth NeoplasmsAtrial Natriuretic FactorHomeostasis

description

AbstractThe natriuretic peptide (NP) system comprises of three ligands, the Atrial Natriuretic Peptide (ANP), Brain Natriuretic peptide (BNP) and C-type Natriuretic peptide (CNP), and three natriuretic peptide receptors, NPRA, NPRB and NPRC. Here we present a comprehensive study of the natriuretic peptide system in healthy murine and human submandibular salivary glands (SMGs). We show CNP is the dominant NP in mouse and human SMG and is expressed together with NP receptors in ducts, autonomic nerves and the microvasculature of the gland, suggesting CNP autocrine signalling may take place in some of these glandular structures. These data suggest the NP system may control salivary gland function during homeostasis through the regulation of electrolyte re-absorption, neural stimulation and/or blood vessel wall contraction/relaxation. We also show abnormal expression of NPRA in the stroma of a subset of human SMGs resected from patients diagnosed with oral squamous cell carcinoma (OSCC) of non-salivary gland origin. This finding warrants further research to investigate a possible correlation between early OSCC invasion and NPRA overexpression.

yearjournalcountryeditionlanguage
2019-11-13Journal of Molecular Histology
https://doi.org/10.1007/s10735-019-09849-5