6533b85bfe1ef96bd12ba102
RESEARCH PRODUCT
A Naturally Occurring Antibody Fragment Neutralizes Infectivity of Diverse Infectious Agents
L.r. TravassosJulián E. MuñozGiulia MoraceRenato A. MortaraPier Paolo ZanelloElisa BorghiLuciano PolonelliSerena GalatiWalter MaglianiStefania ContiTecla CiociolaElisabetta PilottiDenise C. ArrudaClaudio CasoliLaura GiovatiPaola RonziLisa ElviriOriano Marinsubject
0301 basic medicineMicrobial Sensitivity TestsVirus ReplicationArticleMass SpectrometryMicrobiology03 medical and health sciencesAnti-Infective AgentsCandida albicansHumansPhosphorylationCandida albicansInfectivityMultidisciplinaryInnate immune system030102 biochemistry & molecular biologybiologybiology.organism_classificationVirologyPeptide FragmentsIn vitroImmunoglobulin Fc FragmentsGalleria mellonella030104 developmental biologyImmunoglobulin MHumoral immunityHIV-1biology.proteinAntibodyEx vivoChromatography Liquiddescription
AbstractA phosphorylated peptide, named K40H, derived from the constant region of IgMs was detected in human serum by liquid chromatography coupled to high-resolution mass spectrometry. Synthetic K40H proved to exert a potent in vitro activity against fungal pathogens, and to inhibit HIV-1 replication in vitro and ex vivo. It also showed a therapeutic effect against an experimental infection by Candida albicans in the invertebrate model Galleria mellonella. K40H represents the proof of concept of the innate role that naturally occurring antibody fragments may exert against infectious agents, shedding a new light upon the posthumous role of antibodies and opening a new scenario on the multifaceted functionality of humoral immunity.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2016-10-11 | Scientific Reports |