6533b85bfe1ef96bd12ba199
RESEARCH PRODUCT
''Assessment of the use of hypolipidemic agents (HAs), mainly statins, in elderly subjects aged 80 years and more in Burgundy: Analysis of 13,211 patients''
Didier MenuPatrick ManckoundiaAnne Disson-dautricheJean-michel PetitMathieu LorenziniPierre PfitzenmeyerEmmanuel DebostBernard Lorceriesubject
MaleAgingHealth (social science)DiseaseCoronary Artery Disease030204 cardiovascular system & hematologylaw.invention0302 clinical medicineRandomized controlled triallawAVERAGE CHOLESTEROL LEVELS030212 general & internal medicineStrokeHypolipidemic AgentsAged 80 and overFibric AcidsOPEN-LABEL3. Good healthCONTROLLED TRIALHypertensionFemaleFranceSTROKEmedicine.drugmedicine.medical_specialtyAdrenergic beta-AntagonistsDrug Prescriptions03 medical and health sciencesPeripheral Arterial DiseaseDiabetes mellitusInternal medicinemedicineDiabetes MellitusHumansCORONARY-HEART-DISEASEMedical prescriptionCARDIOVASCULAR EVENTSMORTALITY''Polypharmacybusiness.industryMORTALITY[SCCO.NEUR]Cognitive science/NeuroscienceCardiovascular Agentsmedicine.disease''CORONARY-HEART-DISEASEPRAVASTATINPhysical therapyPolypharmacyRISK-FACTORSObservational studyGeriatrics and GerontologyHydroxymethylglutaryl-CoA Reductase InhibitorsbusinessPRIMARY PREVENTIONGerontologyPravastatinPlatelet Aggregation Inhibitorsdescription
Manckoundia, Patrick | Lorenzini, Mathieu | Disson-Dautriche, Anne | Petit, Jean-Michel | Lorcerie, Bernard | Debost, Emmanuel | Menu, Didier | Pfitzenmeyer, Pierre; International audience; ''Only few studies have investigated the use of HA in elderly subjects and there are no data in very elderly subjects. We assessed the prescription of HA and analyzed the relationship between such prescriptions and frailty markers among persons aged 80 and more in an observational study. We recorded the prescriptions for 13,211 patients aged 80-109 years and affiliated to the "Mutualite-Sociale-Agricole (MSA)'' of Burgundy over a 1-month period. The prescription of a HA among all included patients, and the existence of serious long-term disease(s) (LTD), polypharmacy or a prescription of cardiovascular drugs among patients receiving a HA were recorder. Among the 13,211 patients, 3412 aged 80-98 years were treated with an HA. The main HA were statins (70.4%), and fibrates were used in 27.3% of cases. Of these 3412 patients, 2250 had one or several LTD mainly coronaropathy, hypertension, diabetes mellitus or peripheral artery disease. The mean number of drugs per prescription was 6.37. Among subjects treated with HA, 40% also received antiplatelets, 35.6% beta-blockers and 30% inhibitors of the renin-angiotensin system. For 99% of the patients, the prescription of HA was a renewal. Prescribers were mainly general practitioners (96.8%). Statins are the most widely prescribed HA even among very elderly subjects. However, after 80 years the prescription of HA, mainly statins, decreases with aging. This could be explained by polypathology, polypharmacy and the deterioration in metabolic functions which are markers of frailty. This study should encourage research into the use of statins in very elderly subjects. (C) 2011 Elsevier Ireland Ltd. All rights reserved.''
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2012-01-01 |