Strukturbasis und Enzymmechanismus der Biosynthese von C9- aus C10-monoterpenoiden Indol-Alkaloiden

6533b85bfe1ef96bd12ba94d

RESEARCH PRODUCT

Strukturbasis und Enzymmechanismus der Biosynthese von C9- aus C10-monoterpenoiden Indol-Alkaloiden

Joachim Stöckigt Joachim Stöckigt Marco Hill Santosh Panjikar Liuqing Yang Liuqing Yang Meitian Wang

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Alle Neune: Die dreidimensionale Struktur der Polyneuridinaldehyd-Esterase (PNAE) gibt einen Einblick in den Enzymmechanismus der Biosynthese von C9- aus C10-monoterpenoiden Indol-Alkaloiden (siehe Schema). PNAE ist eine sehr substratspezifische Serin-Esterase. Sie enthalt die katalytische Triade S87-D216-H244 und ist ein neues Mitglied der Superfamilie der α/β-Hydrolasen, allerdings mit einer neuartigen Funktion: der Diversifizierung von Alkaloidstrukturen.

year	journal	country	edition	language
2009-06-29	Angewandte Chemie

https://doi.org/10.1002/ange.200900150

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