6533b85bfe1ef96bd12baac3

RESEARCH PRODUCT

Copper-Catalyzed Aerobic Oxidative Alkynylation of 3,4-Dihydroquinoxalin-2-ones

Gonzalo BlayJaume Rostoll-berenguerCarlos VilaJosé R. Pedro

subject

010405 organic chemistryOrganic Chemistrychemistry.chemical_elementOxidative phosphorylation010402 general chemistry01 natural sciencesOxygenCombinatorial chemistryCopperCatalysis0104 chemical sciencesCompostos orgànics SíntesiAlkynylationchemistryCatàlisiCopper catalyzedSurface modificationQuímica orgànica

description

Herein, we described a ligand-free copper-catalyzed aerobic oxidative functionalization of 3,4-dihydroquinoxalin-2(1H)-ones with terminal alkynes using visible-light and oxygen as terminal oxidant to give 3-ethynyl-3,4-dihydroquinoxalin-2(1H)-one, cyclic propargylic amines, in moderate to good yields. Moreover, we demonstrate the versatility of the 3-ethynyl-3,4-dihydroquinoxalin-2(1H)-ones obtained by preparing several 3,4-dihydroquinoxalin-2-one derivatives.

yearjournalcountryeditionlanguage
2019-11-04
10.1055/s-0039-1690244https://doi.org/10.1055/s-0039-1690244