6533b85bfe1ef96bd12bac1a
RESEARCH PRODUCT
Closer to nature: an ATP-driven bioinspired catalytic oxidation process
Nicolas SpinelliDavid MonchaudLoic StefanDamien DuretEric Defrancqsubject
GuanineDeoxyribozymeGuanosineNanotechnology010402 general chemistry01 natural sciencesRedox[ CHIM ] Chemical SciencesCatalysisCatalysischemistry.chemical_compoundAdenosine TriphosphateMaterials Chemistry[CHIM]Chemical SciencesComputingMilieux_MISCELLANEOUS010405 organic chemistryMetals and AlloysDNA CatalyticGeneral Chemistry[CHIM.CATA]Chemical Sciences/Catalysis0104 chemical sciencesSurfaces Coatings and FilmsElectronic Optical and Magnetic MaterialsG-QuadruplexeschemistryCatalytic oxidationScientific methodCeramics and CompositesOxidation-Reductiondescription
The capability of DNA to acquire enzyme-like properties has led to the emergence of the so-called DNAzyme field; herein, we take a further leap along this nature-inspired road, demonstrating that a template assembled synthetic G-quartet (TASQ) can act as a pre-catalyst for catalytic peroxidase-mimicking oxidation reactions, whatever its nature (guanine or guanosine-based G-quartets), in an ATP-dependent manner, thereby bringing this bioinspired TASQzyme process even closer to nature.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2013-01-18 |