6533b85bfe1ef96bd12bb4e7
RESEARCH PRODUCT
Incorporation of lutein and docosahexaenoic acid from dietary microalgae into the retina in quail
Adeline MathiaudPhilippe PouillartE. ClercClémentine ThabuisBertrand RodriguezFlore DepeintCoralie Schnebelen-berthierAnne BourdillonBlandine BaertNiyazi AcarJean-michel LecerfLionel Bretillonsubject
Luteinendocrine systemretinaDocosahexaenoic Acidsgenetic structures030309 nutrition & dietetics[ SDV.AEN ] Life Sciences [q-bio]/Food and NutritionBiological Availability03 medical and health scienceschemistry.chemical_compoundMacular Degenerationdha0302 clinical medicineZeaxanthinsbiology.animal[SDV.IDA]Life Sciences [q-bio]/Food engineeringmedicineAnimalsHumansFood scienceage-related macular degeneration2. Zero hunger0303 health sciencesluteinbiologymicroalgaeFood fortification[ SDV.IDA ] Life Sciences [q-bio]/Food engineeringfood and beveragesRetinalquailMacular degenerationmedicine.diseaseQuaileye diseasesBioavailabilityDietZeaxanthinchemistryBiochemistryDocosahexaenoic acidDietary SupplementsModels Animal030221 ophthalmology & optometrysense organs[SDV.AEN]Life Sciences [q-bio]/Food and NutritionFood Sciencedescription
Abstract Lutein and docosahexaenoic acid (DHA) are associated with the prevention of age-related macular degeneration (AMD). Since microalgae are potent natural sources of these nutrients, their nutritional value should be evaluated based on the bioavailability of lutein and DHA for the retina via the plasmatic compartment. In this study, quail were fed for 5 months either with a diet supplemented or deprived with microalgae rich in lutein and DHA. In the microalgae-fed group, the retinal concentrations of lutein and zeaxanthin gradually increased whereas in plasma, these compounds started to increase from the first month of supplementation. We also observed a significant increase in retinal and plasmatic levels of DHA in the microalgae-fed group. In conclusion, the plasmatic and retinal contents of lutein and DHA were significantly increased in quail fed with lutein- and DHA-rich microalgae. Food fortification with microalgae may be an innovative way to increase lutein and DHA consumption in humans.
year | journal | country | edition | language |
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2015-01-01 |