6533b85bfe1ef96bd12bb580
RESEARCH PRODUCT
Temporal variation in the distribution of type-1 human astrovirus lineages in a settled population over 14 years.
Floriana BonuraVito MartellaSandra MarineoKrisztián BányaiÁKos GellértGiovanni M. GiammancoSimona De Graziasubject
0301 basic medicineSettore MED/07 - Microbiologia E Microbiologia Clinicamedicine.medical_specialtyTime FactorsGenotypePopulationGenome ViralBiology03 medical and health sciencesOpen Reading FramesMedical microbiologyVirologyAstroviridae InfectionsAstrovirus genotyping ItalyGenotypemedicineHumansGenetic variabilityeducationPhylogenyGeneticseducation.field_of_studyGenetic diversityMolecular EpidemiologyGenetic VariationGeneral MedicineHuman astrovirusMolecular analysis030104 developmental biologyItalyMamastrovirusdescription
Human astroviruses (HAstVs) are important enteric pathogens that are genetically and antigenically heterogeneous and can be classified into eight sero/genotypes (HAstV-1 to -8) and different lineages within each HAstV type. This study describes the genetic diversity of HAstVs circulating in southern Italy over 14 years. Molecular analysis of HAstV-1 strains showed that three different lineages (1a, 1b and 1d) of the predominant genotype were circulating during the study period. The study of an archival collection of HAstV strains offers a unique opportunity to evaluate the patterns of variation of HAstV infections over the years and to correlate the observed epidemiological changes to the genetic variability of HAstVs.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2016-02-29 | Archives of virology |