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RESEARCH PRODUCT

Can Clinical and Surgical Parameters Be Combined to Predict How Long It Will Take a Tibia Fracture to Heal? A Prospective Multicentre Observational Study: The FRACTING Study

Francesca De TerlizziFilippo CastoldiSilvio DemitriCarlo De RobertoMariano BorrelliBruno Di MaggioGuglielmo AbateMattia FortinaClaudio CusumanoAlberto MomoliAntonio BarileAntonio GianniniD. Dell'omoAlberto RivaPierluigi AntinolfiCarmelo ScialabbaGiuseppe SolarinoLuca PietrograndeFrancesco BenazzoDomenico AlojUgo BaschieriFrancesco LijoiLuigi CiolliPatrizio CaldoraBiagio MorettiRaffaele FontanaAuro CaraffaStefania SettiPietro PersianiGaetano CarusoLeo MassariEnrico CastamanClaudio CastelliGiuseppe SessaGiuseppe MarongiuMarco GuidiMichelangelo ScaglioneMatteo CadossiPier Bruno SquarzinaVincenzo LorussoVenceslao TovagliaGiovanni GiordanoRoberto RossiLuciano CostarellaAntonio CaponeAntonio PastronePietro CorsiLuigi Branca VerganoEttore DemattèAlessandra La GattutaVincenzo CaiaffaPietro ManiscalcoM’putu BulabulaAndrea MicaglioStefano GherardiMarco RanellucciFilippo La CavaPier Giorgio LondiniMichele GiudiciDario PerugiaMatteo GhiaraGuido BassiClaudio SeverinoVincenzo ZottolaDanilo CastellanoCiro VillaniMauro MonesiAttilio RotaSandro GianniniRuggero CadossiF. FalezMichele D'arienzoPier Luigi De PalmaPaolo FriemelFabio CataniRossano Stefano CornacchiaGiovanni MaraglinoAntonio Pompilio GiganteAlberto Belluati

subject

MaleGenetics and Molecular Biology (all)Immunology and Microbiology (all)lcsh:MedicineTibia fracture multicentre observational studyTibia Fracturefracture; healing; tibiaBiochemistry0302 clinical medicineOsteogenesisMedicineAdolescent; Adult; Female; Fracture Healing; Humans; Male; Middle Aged; Osteogenesis; Prospective Studies; Reproducibility of Results; Tibia; Tibial Fractures; Treatment Outcome; Young AdultProspective Studies030212 general & internal medicineYoung adultProspective cohort studyFracture Healing030222 orthopedicsGeneral MedicineMiddle Agedtibia fractureTreatment OutcomeAdolescent; Adult; Female; Fracture Healing; Humans; Male; Middle Aged; Osteogenesis; Prospective Studies; Reproducibility of Results; Tibia; Tibial Fractures; Treatment Outcome; Young Adult; Biochemistry Genetics and Molecular Biology (all); Immunology and Microbiology (all)Femaletibia fracturetibia FRACTure prediction healINGResearch ArticleAdultmedicine.medical_specialtyArticle SubjectAdolescentBone healingGeneral Biochemistry Genetics and Molecular BiologyNOYoung Adult03 medical and health sciencesHumansIn patientTibiaTime rangetibia FRACTure prediction healINGTibiaGeneral Immunology and Microbiologybusiness.industrylcsh:RReproducibility of ResultsSurgeryTibial FracturesObservational studybusinessBiochemistry Genetics and Molecular Biology (all); Immunology and Microbiology (all)

description

Background. Healing of tibia fractures occurs over a wide time range of months, with a number of risk factors contributing to prolonged healing. In this prospective, multicentre, observational study, we investigated the capability of FRACTING (tibia FRACTure prediction healING days) score, calculated soon after tibia fracture treatment, to predict healing time.Methods. The study included 363 patients. Information on patient health, fracture morphology, and surgical treatment adopted were combined to calculate the FRACTING score. Fractures were considered healed when the patient was able to fully weight-bear without pain.Results. 319 fractures (88%) healed within 12 months from treatment. Forty-four fractures healed after 12 months or underwent a second surgery. FRACTING score positively correlated with days to healing:r=0.63(p<0.0001). Average score value was 7.3 ± 2.5; ROC analysis showed strong reliability of the score in separating patients healing before versus after 6 months: AUC = 0.823.Conclusions. This study shows that the FRACTING score can be employed both to predict months needed for fracture healing and to identify immediately after treatment patients at risk of prolonged healing. In patients with high score values, new pharmacological and nonpharmacological treatments to enhance osteogenesis could be tested selectively, which may finally result in reduced disability time and health cost savings.

yearjournalcountryeditionlanguage
2018-04-01
10.1155/2018/1809091https://hdl.handle.net/11380/1171557