6533b85bfe1ef96bd12bb5ea
RESEARCH PRODUCT
Methylation status of VTRNA2-1/nc886 is stable across populations, monozygotic twin pairs and in majority of tissues.
Saara MarttilaHely TamminenSonja RajićPashupati P MishraTerho LehtimäkiOlli RaitakariMika KähönenLaura KananenJuulia JylhäväSara HäggThomas DelerueAnnette PetersMelanie WaldenbergerMarcus E KleberWinfried MärzRiitta LuotoJani RaitanenElina SillanpääEija K. LaakkonenAino HeikkinenMiina OllikainenEmma Raitoharjusubject
VTRNA2-1EXPRESSIONCancer Researchpolymorphic imprintingväestötutkimusDISEASEnc886Geneticsnoncoding 886COHORTPLACENTAEXPOSUREgeeniekspressioBRAINEPIGENOME-WIDE ASSOCIATIONRISKDNA methylationgeenit1184 Genetics developmental biology physiologyDna Methylation ; Vtrna2-1 ; Developmental Origins Of Health And Disease Hypothesis ; Imprinting ; Metastable Epiallele ; Nc886 ; Noncoding 886 ; Polymorphic Imprinting ; Population Studiespopulation studies217 Medical engineeringmetastable epialleleDNA-metylaatiodevelopmental origins of health and disease hypothesisHEALTH3111 Biomedicineimprintingdescription
Aims & methods: The aim of this study was to characterize the methylation level of a polymorphically imprinted gene, VTRNA2-1/nc886, in human populations and somatic tissues.48 datasets, consisting of more than 30 tissues and >30,000 individuals, were used. Results: nc886 methylation status is associated with twin status and ethnic background, but the variation between populations is limited. Monozygotic twin pairs present concordant methylation, whereas similar to 30% of dizygotic twin pairs present discordant methylation in the nc886 locus. The methylation levels of nc886 are uniform across somatic tissues, except in cerebellum and skeletal muscle. Conclusion: The nc886 imprint may be established in the oocyte, and, after implantation, the methylation status is stable, excluding a few specific tissues. Tweetable abstract Methylation status of a polymorphically imprinted gene, VTRNA2-1/nc886, is stable in human populations (48 cohorts, n > 30,000) and in somatic tissues, except in cerebellum and skeletal muscle. Twin data suggest it may already be established in the oocyte. Peer reviewed
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2022-09-01 |