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RESEARCH PRODUCT
Dendritic Ih selectively blocks temporal summation of unsynchronized distal inputs in CA1 pyramidal neurons.
Michele MiglioreMichele MiglioreMichele FerranteL. Messineosubject
N-MethylaspartateTime FactorsComputer scienceCognitive NeuroscienceModels NeurologicalNeural ConductionHippocampal formationSummationHippocampusSynaptic TransmissionCA1Cellular and Molecular NeurosciencemedicineExcitatory Amino Acid AgonistsAnimalsComputer Simulationalpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic AcidI-hProbabilityCa1 pyramidal neuronPyramidal CellsExcitatory Postsynaptic PotentialsReproducibility of ResultsmodelingDendritesSensory Systemsdendritic integrationmedicine.anatomical_structurenervous systemSomaNeuronNeurosciencedescription
The active dendritic conductances shape the input-output properties of many principal neurons in different brain regions, and the various ways in which they regulate neuronal excitability need to be investigated to better understand their functional consequences. Using a realistic model of a hippocampal CA1 pyramidal neuron, we show a major role for the hyperpolarization-activated current, I-h, in regulating the spike probability of a neuron when independent synaptic inputs are activated with different degrees of synchronization and at different distances from the soma. The results allowed us to make the experimentally testable prediction that the I-h in these neurons is needed to reduce neuronal excitability selectively for distal unsynchronized, but not for synchronized, inputs.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2004-01-07 |