6533b85bfe1ef96bd12bb73d
RESEARCH PRODUCT
Binding and neurotoxicity mitigation of toxic tau oligomers by synthetic heparin like oligosaccharides.
Xuefei HuangFilippa Lo CascioFilippa Lo CascioJia GaoPeng WangRakez Kayedsubject
0301 basic medicineHeparin likeMetals and AlloysNeurotoxicityGeneral ChemistryHeparinmedicine.diseaseOligomerCatalysisArticleSurfaces Coatings and FilmsElectronic Optical and Magnetic Materials03 medical and health scienceschemistry.chemical_compound030104 developmental biologyBiochemistrychemistrymental disordersMaterials ChemistryCeramics and CompositesmedicineCytotoxicitymedicine.drugdescription
Well-defined heparin like oligosaccharides up to decasaccharides were synthesized. It was discovered for the first time that heparin oligosaccharides, as short as tetrasaccharides, can bind with the most toxic tau species, i.e., tau oligomers with nM KD. The binding significantly reduced the cellular uptake of toxic tau oligomers and protected the cells from tau oligomer induced cytotoxicity.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2018-08-22 | Chemical communications (Cambridge, England) |