6533b85bfe1ef96bd12bb767
RESEARCH PRODUCT
Reactivation of chronic type B hepatitis: the effect on expression of serum HBV-DNA and pre-S encoded proteins.
K H Meyer Zum BüschenfeldeMichael MannsGeorg HessWeber CG. Gerkensubject
AdultMaleAdolescentBiologyLiver diseaseAntigenVirologymedicineCytotoxic T cellHumansHepatitis B e AntigensProtein PrecursorsHepatitis ChronicHepatitisHepatitis B Surface AntigensHepatobiliary diseaseHepatitis BMiddle Agedmedicine.diseaseHepatitis BVirologyInfectious DiseasesHBeAgViral replicationDNA ViralFemaledescription
Hepatitis B markers were studied in seven patients with reactivated liver disease. Reactivation of chronic type B hepatitis, as indicated by the reappearance of hepatitis B e antigen (HBeAg) in the serum, was characterised by the appearance of hepatitis B virus-DNA (HBV-DNA) in the serum. The expression of pre-S 1 encoded protein remained unchanged in five of seven patients, and poly-HSA as a marker for pre-S 2 encoded protein remained detectable in six of seven patients before and after reactivation of chronic hepatitis. The level of serum HBV-DNA correlated well with the level of liver enzymes, which rose from normal to various levels after reactivation of the liver disease. The data suggest that inflammatory activity of the liver disease is not related to the expression of pre-S encoded protein but to viral replication. Possibly pre-C and C-gene encoded antigens, which are produced together with viral nucleic acid and expressed on the surface of HBV-infected liver cells, play the key role in liver damage believed to be mediated by cytotoxic T cells.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1988-06-01 | Journal of medical virology |