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RESEARCH PRODUCT
Polyphosphate as a Bioactive and Biodegradable Implant Material: Induction of Bone Regeneration in Rats
Emad TolbaWerner E.g. MüllerBärbel Diehl-seifertShunfeng WangFeng HeHeinz C. SchröderXiaohong Wangsubject
0301 basic medicineMaterials sciencePolyphosphateCalvaria02 engineering and technology021001 nanoscience & nanotechnologyCondensed Matter PhysicsPhosphatedigestive system diseasesIn vitro03 medical and health scienceschemistry.chemical_compoundPLGA030104 developmental biologymedicine.anatomical_structurechemistryIn vivomedicineGeneral Materials ScienceImplant0210 nano-technologyBone regenerationBiomedical engineeringdescription
Inorganic polyphosphate (polyP) is a naturally occurring polymer that is bioresorbable and anabolically active on bone forming cells in vitro. In order to demonstrate if polyP also shows morphogenetic activity in vivo, animal studies are performed applying the rat calvarial defect model. Poly(D,L-lactide-co-glycolide) (PLGA) microspheres with a narrow size distribution (≈820 μm) are prepared, containing either encapsulated polyP or β-tricalcium phosphate (β-TCP), used as a reference material. Discs are prepared from the microspheres and inserted into 10 mm large defects created in the calvaria of rats. Both the formation of COL-I and the expression of ALP is upregulated, as well as the extent of mineralization within and around the polyP implant. Our data demonstrate that amorphous and resorbable inorganic polyP is also morphogenetically active in vivo.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2016-04-23 | Advanced Engineering Materials |