6533b85bfe1ef96bd12bbe43
RESEARCH PRODUCT
Effects of tributyltin(IV) chloride exposure on early embryonic stages ofCiona intestinalis:In vivo and ultrastructural investigations
Giuseppe DolcemascoloMario GianguzzaLorenzo PelleritoC. Mansuetosubject
animal structuresbiologyChemistryInorganic chemistryEmbryogenesisEmbryoGeneral Chemistrybiology.organism_classificationCleavage (embryo)ChlorideCell biologyInorganic Chemistrychemistry.chemical_compoundIn vivoembryonic structuresmedicineTributyltinUltrastructureCiona intestinalismedicine.drugdescription
The effects of tributyltin(IV) chloride (TBT chloride) solutions on ascidian embryos of Ciona intestinalis have been tested at different stages of development. It has been observed, in vivo, that TBT chooride inhibited cleavage of fertilized eggs and of embryo blastomeres giving rise to cellular masses that are not delimited by plasma membrane. Electron-dense precipitates of TBT chloride, probably as inorganic tin, have been observed by transmission electron microscopy in the egg cytoplasm of cellular masses. The same type of precipitate was present also inside the mitochondria, whose structure appeared to be highly modified. These ultrastructure aspects are indicative of a degenerative process of the embroys after incubation in TBT chloride.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1993-10-01 | Applied Organometallic Chemistry |