6533b85bfe1ef96bd12bbe66
RESEARCH PRODUCT
Oxycodone extended release capsules for the treatment of chronic pain
Sebastiano Mercadantesubject
medicine.medical_specialtyCapsules03 medical and health sciences0302 clinical medicine030202 anesthesiologymedicineHumansPharmacology (medical)In patientChildIntensive care medicinebusiness.industryGeneral NeuroscienceChronic painHave Difficulty Swallowingmedicine.diseaseLow back painAnalgesics OpioidOpioidPrescription opioidDelayed-Action PreparationsAnesthesiaNeurology (clinical)Chronic Painmedicine.symptomExtended releasebusinessOxycodoneOxycodone030217 neurology & neurosurgerymedicine.drugdescription
As a consequence of greater prescription opioid utilization, there has been the parallel increase in misuse, abuse, and overdose, which are serious risks. Associated new formulations may be safer. Areas covered: The introduction of abuse-deterrent opioid formulations and continuous programs to improve opioid prescribing practices may limit the opioid abuse and its consequences. Oxycodone extended release capsules are an extended-release (ER), microsphere-in-capsule abuse-deterrent-formulation designed to retain its extended-release properties following tampering or misuse (e.g., chewing, crushing). Studies have reported that this preparation is efficacious in patients with low back pain, less attractive for illicit use, and an option for patients who have difficulty swallowing and erroneously crush their medication. Expert commentary: Preliminary data regarding oxycodone extended release capsules are encouraging. However, more data in different populations are necessary to confirm initial observations, and comparison should be performed with active substances.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2017-03-10 | Expert Review of Neurotherapeutics |