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RESEARCH PRODUCT

Exercise cardiac power and the risk of heart failure in men: A population-based follow-up study.

Sudhir KurlMagnus J HagnäsSae Young JaeAri VoutilainenJussi KauhanenTimo H. MäkikallioJari A. LaukkanenJari A. Laukkanen

subject

Malemedicine.medical_specialtyeducationPopulationPhysical Therapy Sports Therapy and RehabilitationPopulation basedCohort Studies03 medical and health sciencesfluids and secretions0302 clinical medicineInternal medicineMedicineHumansOrthopedics and Sports Medicine030212 general & internal medicineeducationExerciseHeart Failureeducation.field_of_studybusiness.industryFollow up studiesVO2 max030229 sport sciencesmedicine.diseasePrognosisBlood pressureQuartileHeart failureCardiologybusinessCohort studyFollow-Up Studies

description

Little is known about exercise cardiac power (ECP), defined as the ratio of directly measured maximal oxygen uptake with peak systolic blood pressure during exercise, on heart failure (HF) risk. We examined the association of ECP and the risk of HF.This was a population-based cohort study of 2351 men from eastern Finland. The average time to follow-up was 25 years. Participants participated at baseline in an exercise stress test. A total of 313 cases of HF occurred.Men with low ECP (9.84 mL/mmHg, the lowest quartile) had a 2.37-fold (95% confidence interval (95%CI): 1.68-3.35, p0.0001) hazards ratio of HF as compared with men with high ECP (13.92 mL/mmHg, the highest quartile), after adjusting for age. Low ECP was associated with a 1.96-fold risk (95%CI: 1.38-2.78, p0.001) of HF after additional adjustment for conventional risk factors. After further adjustment for left ventricular hypertrophy, the results hardly changed (hazards ratio = 1.87, 95%CI: 1.31-2.66, p0.001). One SD increase in ECP (3.16 mL/mmHg) was associated with a decreased risk of HF by 28% (95%CI: 17%-37%).ECP provides a noninvasive and easily available measure from cardiopulmonary exercise tests in predicting HF. However, ECP did not provide additional value over maximal oxygen uptake

10.1016/j.jshs.2020.02.008https://pubmed.ncbi.nlm.nih.gov/35367042