6533b85cfe1ef96bd12bc036
RESEARCH PRODUCT
Chromosomal changes in renal oncocytomas Evidence that t(5;11)(q35;q13) may characterize a second subgroup of oncocytomas
S. StörkelJw OosterhuisTrijnie DijkhuizenH.j.a. MensinkE. Van Den BergB. De JongA. DamG. Brutel De La Rivièresubject
AdenomaMalecongenital hereditary and neonatal diseases and abnormalitiesCancer ResearchMonosomyPathologymedicine.medical_specialtyChromosomal translocationBiologyurologic and male genital diseasesY chromosomeTranslocation GeneticGeneticsmedicineHumansOncocytomaMolecular BiologyAgedChromosome AberrationsGeneticsChromosome 7 (human)KidneyChromosomes Human Pair 11ChromosomeCancerMiddle Agedmedicine.diseaseKidney Neoplasmsmedicine.anatomical_structureKaryotypingChromosomes Human Pair 5Femaledescription
Many of the reported oncocytomas have different chromosome abnormalities, indicating that they comprise a cytogenetically heterogenous group of tumors consisting of potentially cytogenetic subgroups. We have performed cytogenetic studies on nine renal oncocytomas. Clonal abnormalities were present in eight tumors. The findings most observed were the loss of the Y chromosome, and abnormalities of chromosomes 1 and 22. We also observed telomeric associations (tas) in two tumors and structural aberrations of chromosomes 9p and 19q, as well as monosomy 10. In two cases we found a similar reciprocal t(5;11)(q35;q13) in two cases. Review of the literature disclosed one other oncocytoma with a t(5;11) (q35;q13). This suggests that t(5;11)(q35;q13) defines a (second) subset of oncocytomas apart from the subgroup specifically associated with the loss of chromosomes 1 and Y.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1995-02-01 | Cancer Genetics and Cytogenetics |