6533b85cfe1ef96bd12bc13a

RESEARCH PRODUCT

Molecular rearrangements of 1-oxa-2-azoles as an expedient route to fluorinated heterocyclic compounds

Nicolò VivonaSilvestre BuscemiAndrea PaceIvana Pibiri

subject

PharmacologyQuinazolin-4-oneChemistryOrganic ChemistryOrganic chemistrySettore CHIM/06 - Chimica OrganicaGeneral MedicinePhotochemistry Fluorinated Oxadiazole Fluorinated Triazole Quinazolin-4-oneCombinatorial chemistryAnalytical Chemistry

description

Molecular rearrangements of O-N bond-containing azoles (1-oxa-2- azoles) represent a wide class of reactions by which various heterocycle-to- heterocycle transformations can be performed as alternative synthetic methodologies. The material presented in this review is an extensive survey of both thermal and photochemical methodologies that have been applied to fluorinated oxadiazoles, and shows how molecular rearrangements can be an alternative and in some cases the most convenient route for the synthesis of several fluorinated heterocycles.

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