6533b85cfe1ef96bd12bc85b

RESEARCH PRODUCT

Direct determination of tautomerism in purine derivatives by low-temperature NMR spectroscopy

Vladimír SklenářMichal HocekDana HockováKateřina MaliňákováErkki KolehmainenPavlína SečkářováRadek Marek

subject

Purine010405 organic chemistryChemistryStereochemistryCarbon-13 NMR satelliteOrganic ChemistryNuclear magnetic resonance spectroscopy010402 general chemistry01 natural sciencesBiochemistryTautomer3. Good health0104 chemical scienceschemistry.chemical_compoundComputational chemistryDrug DiscoveryPurine derivative

description

An investigation of the purine derivatives N,N-dimethyl-N'-(7(9)-H-purin-6-yl)-formamidine, 6-chloropurine and 6-methoxy purine at low temperatures by NMR spectroscopy has been carried out. Low temperature enabled us in two cases to detect the separate NMR signals of N7-H and N9-H tautomers.

yearjournalcountryeditionlanguage
2004-08-01Tetrahedron Letters
https://doi.org/10.1016/j.tetlet.2004.06.088