0000000001046296

AUTHOR

Pavlína Sečkářová

showing 2 related works from this author

NMR Quantification of Tautomeric Populations in Biogenic Purine Bases

2009

Purine bases such as purine, adenine, hypoxanthine, and mercaptopurine are known to exist in several tautomeric forms. Characterization of their tautomeric equilibria is important not only for predicting the regioselectivity of their N-alkylation reactions but also for gaining knowledge of the patterns with which these compounds of significant biological activity form hydrogen bonds with their biological targets. Low-temperature 1H- and 13C-NMR spectroscopy were used to investigate the tautomeric equilibria for purine and some purine derivatives in methanol and N,N-dimethylformamide solutions. The N(7)H and N(9)H tautomeric forms were quantified by integrating the individual 1H NMR signals …

Purineeducation.field_of_study010405 organic chemistryHydrogen bondChemistryStereochemistryOrganic ChemistryPopulationNuclear magnetic resonance spectroscopy010402 general chemistry01 natural sciencesTautomer0104 chemical sciences3. Good healthchemistry.chemical_compoundProton NMRPhysical and Theoretical ChemistryPurine metabolismeducationHypoxanthineEuropean Journal of Organic Chemistry
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Direct determination of tautomerism in purine derivatives by low-temperature NMR spectroscopy

2004

An investigation of the purine derivatives N,N-dimethyl-N'-(7(9)-H-purin-6-yl)-formamidine, 6-chloropurine and 6-methoxy purine at low temperatures by NMR spectroscopy has been carried out. Low temperature enabled us in two cases to detect the separate NMR signals of N7-H and N9-H tautomers.

Purine010405 organic chemistryChemistryStereochemistryCarbon-13 NMR satelliteOrganic ChemistryNuclear magnetic resonance spectroscopy010402 general chemistry01 natural sciencesBiochemistryTautomer3. Good health0104 chemical scienceschemistry.chemical_compoundComputational chemistryDrug DiscoveryPurine derivativeTetrahedron Letters
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