6533b85cfe1ef96bd12bc8aa

RESEARCH PRODUCT

Aspergilosis invasora en el paciente con enfermedad oncohematológica

Carlos SolanoLourdes Vazquez

subject

0301 basic medicineAntifungalmedicine.drug_classbusiness.industrymedicine.medical_treatment030106 microbiologyHematopoietic stem cell transplantationAspergillosismedicine.diseaseMicrobiology03 medical and health sciencesInfectious DiseasesHematological DiseasesImmunityImmunologymedicineIn patientbusiness

description

Invasive aspergillosis is the most common invasive fungal infection in patients with acute hematological malignancies or treated with hematopoietic stem cell transplantation due to the marked alteration of the physiological mechanisms of antifungal immunity that takes place in these situations. For this reason, antifungal prophylaxis has a relevant role in these patients. The introduction of new antifungal agents has motivated the updating of recommendations for prophylaxis and treatment in different guidelines. The objectives of this chapter are a brief review of the mechanisms of immunity against fungi, the definition of risk for developing an invasive fungal infection and an update of the prophylaxis recommendations and treatment of invasive aspergillosis in the group of patients with hematological diseases.

https://doi.org/10.1016/j.riam.2018.10.001