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RESEARCH PRODUCT

Lack of evidence of hepatitis in patients with oral lichen planus in China: A case control study

Xiaodan LiuSha SuYing HanJiangyuan SongHongwei LiuXiaoli JiZhihui ZhangSi XuDongdong Mu

subject

AdultMaleChinamedicine.medical_specialtyHepatitis C virusOdontologíamedicine.disease_causeGastroenterologyVirusHepatitis B Antigens030207 dermatology & venereal diseases03 medical and health sciencesLiver diseaseHepatitis B Chronic0302 clinical medicinestomatognathic systemInternal medicineHumansMedicineGeneral DentistryHepatitis B virusHepatitisOral Medicine and Pathologyintegumentary systembusiness.industryResearchvirus diseases030206 dentistryHepatitis CHepatitis C AntibodiesHepatitis C ChronicMiddle AgedHepatitis B:CIENCIAS MÉDICAS [UNESCO]medicine.diseaseCiencias de la saludVirologydigestive system diseasesstomatognathic diseasesOtorhinolaryngologyCase-Control StudiesUNESCO::CIENCIAS MÉDICASFemaleSurgeryOral lichen planusbusinessLichen Planus Oral

description

Background: China has been one of the countries with high prevalence of chronic hepatitis B virus (HBV) and hepatitis C virus (HCV) liver disease. And lichen planus is an extrahepatic manifestation of patients with chronic HCV infection. This case-control study was conducted to investigate the relationship between oral lichen planus (OLP) and HBV/HCV infection in China. Material and Methods: A total of 776 patients, including 150 patients with OLP (Group OLP), 429 inpatients from the Trauma Ward of Oral and Maxillofacial Surgery Department (Group A), 110 patients with other oral mucosal diseases, but without a reported association with HCV infection (Group B) and 87 patients with oral lichenoid lesion (Group OLL), were compared with their seroprevalence of anti-HCV antibody (HCVAb), hepatitis B surface antigen (HBsAg) and the parameters of liver functions. Moreover, the clinical characteristics of OLP were also observed, such as gender, age, chief complaint, course of the disease, clinical type, sites involved and so on. Results: The positive rates of HCVAb and HBsAg in OLP patients were 0.7% and 4%, respectively. Neither HCVAb nor HBsAg was associated with OLP as demonstrated by both the univariate and the multivariate analyses. The clinical features and liver functions of OLP patients with negative or positive HBsAg were nearly the same. Conclusions: Our findings verify that there is no association between OLP and hepatitis and there is no need to run a screening test for HCV or HBV in OLP patients in China

yearjournalcountryeditionlanguage
2016-01-01Medicina Oral Patología Oral y Cirugia Bucal
https://doi.org/10.4317/medoral.20812