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RESEARCH PRODUCT

Prevalence of salivary Epstein-Barr virus in potentially malignant oral disorders and oral squamous cell carcinoma.

Judith Murillo-cortesRafael Medina-gonzalezJose-v BaganManuel Leopoldo-rodadoJose-m Díaz-fernándezConcepción Gimeno-cardonaMaría-dolores Ocete-monchonLeticia Bagan

subject

AdultMalemedicine.medical_specialtySalivaHerpesvirus 4 HumanCellOdontologíamedicine.disease_causeGastroenterologyVirus03 medical and health sciencesYoung Adult0302 clinical medicineInternal medicineCarcinomamedicineHumansBasal cellYoung adultSalivaGeneral DentistryAgedMouth neoplasmAged 80 and overOral Medicine and Pathologybusiness.industryResearch030206 dentistryMiddle Agedmedicine.disease:CIENCIAS MÉDICAS [UNESCO]Epstein–Barr virusCiencias de la saludstomatognathic diseasesmedicine.anatomical_structureOtorhinolaryngology030220 oncology & carcinogenesisUNESCO::CIENCIAS MÉDICASImmunologyDNA ViralCarcinoma Squamous CellSurgeryFemaleMouth NeoplasmsbusinessMouth Diseases

description

Background: To analyze the presence of salivary Epstein-Barr virus (EBV) DNA in oral squamous cell carcinoma and potentially malignant oral disorders. Material and Methods: Three groups were studied: Group 1 (12 oral squamous cell carcinomas (OSCC)), Group 2 (12 potentially malignant oral disorders (PMD)) and Group 3 (47 healthy controls). EBV DNA salivary analysis was performed by PCR. Results: The highest percentage of positive salivary EBV DNA corresponded to the OSCC group (58.3%), followed by the PMD group (41.7%) and the controls (40.4%). The differences between groups were not statistically significant, however (p>0.05). Conclusions: Salivary EBV DNA was more prevalent in OSCC than in PMD or the controls. Sin financiación 1.156 JCR (2016) Q3, 63/90 Dentistry, Oral Surgery & Medicine UEV

yearjournalcountryeditionlanguage
2015-04-18Medicina oral, patologia oral y cirugia bucal
10.4317/medoral.20785https://pubmed.ncbi.nlm.nih.gov/26827058