6533b85cfe1ef96bd12bd31c

RESEARCH PRODUCT

Neurotrophic and neuroprotective effects of muscle contraction

Antonio PintoDomenico Di RaimondoAntonino TuttolomondoValentina Arnao

subject

0301 basic medicinemedicine.medical_specialtyDiseaseBioinformaticsNeuroprotection03 medical and health sciencesEpilepsyPhysical medicine and rehabilitationDrug DiscoverymedicineHumansDementiaNervous System Physiological PhenomenaAmyotrophic lateral sclerosisStrokeExerciseLife StyleNervous System DiseaseDepression (differential diagnoses)EndocannabinoidPharmacologybusiness.industryPhysical activityMultiple sclerosisPreventionBrain-Derived Neurotrophic FactorRehabilitationOxidative Stremedicine.diseaseLifestyleStrokeOxidative Stress030104 developmental biologyCerebrovascular CirculationDementiaNervous System DiseasesbusinessNeurological diseaseEndocannabinoidsHumanMuscle Contraction

description

Background: Physical activity has been shown to be associated with reduced risk of coronary heart disease but the same effect seems to be produced in neurological diseases. Objective: In this review, we focused on the interplay between physical activity and some neurological conditions (Stroke, dementia, epilepsy, headache, Parkinson’ s disease, amyotrophic lateral sclerosis, multiple sclerosis, insomnia, depression and anxiety) with the aim of describing the potential role of physical activity in the prevention of such diseases and the physiological mechanisms involved in these processes. Results: Despite a growing body of evidence which reveals that physical activity is able to reduce the frequency of neurological diseases, directly or indirectly by enhancing cardiovascular conditions, further studies are necessary to better characterize which type of exercise is useful for each condition. Conclusion: Physical activity could represent an additional approach to fight against such diseases.

10.2174/1381612822666160428111234http://hdl.handle.net/10447/414984