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RESEARCH PRODUCT
Haemorheological profile in congenital afibrinogenemia and in congenital dysfibrinogenemia: A clinical case report
Eugenia HoppsSimona RasoSergio SiragusaMariasanta NapolitanoGregorio CaimiR. Lo Prestisubject
AdultMaleHypoviscosityPediatricsmedicine.medical_specialtyPhysiologyHyperviscosity030204 cardiovascular system & hematologyFibrinogen030218 nuclear medicine & medical imagingYoung Adult03 medical and health sciences0302 clinical medicinePhysiology (medical)medicineHumansAfibrinogenemiabusiness.industryCongenital dysfibrinogenemiaFibrinogenHematologyMiddle AgedAfibrinogenemiamedicine.diseaseCongenital afibrinogenemiaVenous thrombosisFemaleClinical caseCardiology and Cardiovascular MedicinebusinessHumanmedicine.drugdescription
Although the inherited quantitative and qualitative disorders of fibrinogen are rare, in the course of time patients may develop complications including episodes of arterial and venous thrombosis. It can be useful to complete the laboratory assessment of these clinical conditions with the evaluation of the haemorheological profile. The data obtained from this study showed that congenital afibrinogenemia was characterized by a primary plasma hypoviscosity, whereas congenital dysfibrinogenemia by a primary plasma hyperviscosity. Both these haemorheological alterations may concur, with different mechanisms, to the pathogenesis of thrombotic vascular complications.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2019-07-16 | Clinical Hemorheology and Microcirculation |