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RESEARCH PRODUCT

Comparative Analysis of Cell Proliferation Ratio in Oral Lichen Planus, Epithelial Dysplasia and Oral Squamous Cell Carcinoma

Thaís Cachuté ParadellaLuiz Eduardo Blumer RosaFernando Augusto Cervantes Garcia De SousaYasmin Rodarte Carvalho

subject

Epithelial dysplasiaPathologymedicine.medical_specialtyAgnorstomatognathic systemOral and maxillofacial pathologyepithelial dysplasiaCarcinomaMedicineHumansBasal cellskin and connective tissue diseasesGeneral DentistryCell Proliferationintegumentary systembusiness.industryCell growthMouth Mucosamedicine.disease:CIENCIAS MÉDICAS [UNESCO]oral squamous cell carcinomastomatognathic diseasesOtorhinolaryngologyUNESCO::CIENCIAS MÉDICASOral lichen planusimmunohistochemistryCarcinoma Squamous CellImmunohistochemistrySurgeryOral lichen planusMouth NeoplasmsbusinessLichen Planus Oral

description

Made available in DSpace on 2013-08-12T18:47:57Z (GMT). No. of bitstreams: 0 Previous issue date: 2009-11-01 Made available in DSpace on 2013-09-30T18:34:12Z (GMT). No. of bitstreams: 0 Previous issue date: 2009-11-01 Submitted by Vitor Silverio Rodrigues (vitorsrodrigues@reitoria.unesp.br) on 2014-05-20T14:04:33Z No. of bitstreams: 0 Made available in DSpace on 2014-05-20T14:04:33Z (GMT). No. of bitstreams: 0 Previous issue date: 2009-11-01 Background: Although oral lichen planus has been classified by the World Health Organization (WHO) as a potentially malignant disorder, such classification is still the target of much controversy. Aim: To evaluate the cell proliferation rate in oral lichen planus, comparing it to the rate observed in epithelial dysplasia and oral squamous cell carcinoma, aiming at indications which might indicate the potential for malignant transformation. Material and Methods: Twenty-four cases of each lesion were submitted to the streptoavidin-biotin and AgNOR technique to evaluate the immunohistochemical expression of PCNA and the mean NORs/ nucleus, respectively. Results: Positivity for PCNA was observed in 58.33% of oral lichen planus cases, 83.33% of epithelial dysplasia cases and 91.67% of oral squamous cell carcinoma cases. Chi-squared test showed that the number of positive cases for PCNA was significantly lower in oral lichen planus than in oral squamous cell carcinoma (p0.05) and between the epithelial dysplasia and oral squamous cell carcinoma (p>0.05) was observed. The mean NORs/ nucleus in oral lichen planus, epithelial dysplasia and oral squamous cell carcinoma were 1.74 +/- 0.32, 2.42 +/- 0.62 e 2.41 +/- 0.61, respectively. Variance analysis (ANOVA) revealed significant statistical difference between oral lichen planus and the other studied lesions (p<0.05). Conclusion: Oral lichen planus cell proliferation rate was less than in oral epithelial dysplasia and oral squamous cell carcinoma which might explain the lower malignant transformation rate. São Paulo State Univ, Sao Jose dos Campos Dent Sch, Dept Biosci & Oral Diag, Sao Jose Dos Campos, SP, Brazil São Paulo State Univ, Sao Jose dos Campos Dent Sch, Dept Biosci & Oral Diag, Sao Jose Dos Campos, SP, Brazil

yearjournalcountryeditionlanguage
2009-01-01
http://hdl.handle.net/10550/60609