6533b85cfe1ef96bd12bd5f1

RESEARCH PRODUCT

Polypharmacy in older people: lessons from 10 years of experience with the REPOSI register

Pier Mannuccio MannucciAlessandro NobiliLuca PasinaPier Mannuccio MannucciMauro TettamantiCarlotta FranchiSalvatore CorraoAlessandra MarengoniFrancesco SalernoMatteo CesariFrancesco PerticoneGiuseppe LicataFrancesco VioliGino Roberto CorazzaCarlotta FranchiLaura CortesiMauro TettamantiLaura CortesiIlaria ArdoinoDomenico PriscoElena SilvestriCaterina CenciGiacomo EmmiGianni BioloMichela ZanettiMartina GuadagniMichele ZaccariMassimo VanoliGiulia GrignaniEdoardo Alessandro PulixiMauro BernardiSilvia Li BassiLuca SantiGiacomo ZaccheriniElmo MannarinoGraziana LupattelliVanessa BianconiFrancesco PaciulloRanuccio NutiRoberto ValentiMartina RuvioSilvia CappelliAlberto PalazzuoliOliviero OlivieriDomenico GirelliThomas MatteazziMario BarbagalloLigia DominguezFloriana CocitaVincenza BeneduceLidia PlancesMarco ZoliIlaria LazzariMattia BrunoriFranco Laghi PasiniPier Leopoldo CapecchiGiuseppe PalascianoMaria Ester ModeoCarla Di GennaroMaria Domenica CappelliniDiletta MairaValeria Di StefanoGiovanna FabioSonia SeghezziMarta MancarellaMatteo CesariPaolo Dionigi RossiSarah DamantiMarta ClericiFederica ContiGino Roberto CorazzaEmanuela MiceliMarco Vincenzo LentiMartina PisatiCostanza Caccia DominioniGiovanni MurialdoAlessio MarraFederico CattaneoMaria Beatrice SecchiDavide GhelfiLuigi AnastasioLucia SofiaMaria CarboneFrancesco CipolloneMaria Teresa GuagnanoErmanno AngelucciEmanuele ValerianiGerardo MancusoDaniela CalipariMosè BartoneGiuseppe DelitalaMaria BerriaMaurizio MuscaritoliAlessio MolfinoEnrico PetrilloGiuseppe ZuccalàGabriella D’aurizioGiuseppe RomanelliAlessandra MarengoniAlberto ZucchelliAntonio PicardiUmberto Vespasiani GentilucciPaolo GalloChiara Dell’untoGiorgio AnnoniMaurizio CorsiGiuseppe BellelliSara ZazzettaPaolo MazzolaHajnalka SzaboAlessandra BonfantiFranco ArturiElena SuccurroMariangela RubinoMaria Grazia SerraMaria Antonietta BleveLaura GasbarroneMaria Rosaria SajevaAntonio BrucatoSilvia GhidoniFabrizio FabrisIrene BertozziGiulia BogoniMaria Victoria RabuiniElisabetta CosiRoberto ManfrediniFabio FabbianBenedetta BoariAlfredo De GiorgiRuana TiseoGiuseppe PaolissoMaria Rosaria RizzoClaudio BorghiEnrico StrocchiValeria De SandoIlenia PareoCarlo SabbàFrancesco Saverio VellaPatrizia SuppressaPasquale AgostiAndrea SchilardiFrancesca LoparcoLuigi FenoglioChristian BraccoAlessia Valentina GiraudoSilvia FargionGiulia PeritiMarianna PorzioSlivia TiraboschiFlora PeyvandiRaffaella RossioBarbara FerrariGiulia ColomboValter MonzaniValeria SavojardoChristian FolliGiuliana CerianiFrancesco SalernoGiada PalliniFranco DallegriLuciano OttonelloLuca LiberaleLara CaserzaKassem SalamNicola Lucio LiberatoTiziana TogninGiovanni Battista BianchiSabrina GiaquintoFrancesco PurrelloAntonino Di PinoSalvatore PiroRenzo RozziniLina FalangaElena SpazziniCamillo FerrandinaGiuseppe MontrucchioPaolo PetittiRaffaella SalmiPiergiorgio GaudenziFrancesco VioliLudovica PerriRaffaele LandolfiMassimo MontaltoAntonio MirijelloLuigina GuastiLuana CastiglioniAndrea MarescaAlessandro SquizzatoMarta MolaroAlessandra GrossiMarco BertolottiChiara MussiMaria Vittoria LibbraGiulia DondiElisa PellegriniLucia CarulliFrancesco PerticoneLidia ColangeloTania FalboVincenzo StanghelliniRoberto De GiorgioEugenio RuggeriSara Del VecchioAndrea SalviRoberto LeonardiGiampaolo DamianiArmando GabrielliWilliam CapeciMassimo MattioliGiuseppe Pio MartinoLorenzo BiondiPietro PettinariRiccardo GhioAnna Dal ColSalvatore MinisolaLuciano ColangeloAntonella AfeltraBenedetta MariglianoMaria Elena PipitaPietro CastellinoJulien BlancoLuca ZanoliSamuele PignataroValter SaraccoMarisa FogliatiCarlo BussolinoFrancesca MeteMiriam GinoAntonio CittadiniCarlo VigoritoMichele ArcopintoAndrea SalzanoEmanuele BobbioAlberto Maria MarraDomenico SiricoGuido MoreoFrancesca GaspariniSilvia ProloGloria PinaAlberto BallestreroFabio FerrandoSergio BerraSimonetta DassiMaria Cristina NavaBruno GraziellaStefano BaldassarreSalvatore FragapaniGabriella GrudenGiorgio GalantiGabriele MascheriniCristian PetriLaura StefaniMargherita GirinoValeria PiccinelliFrancesco NassoVincenza GioffrèMaria Grazia Di PasqualeGiuseppe ScattolinSergio MartinelliMauro TurrinLeonardo SechiCristina CatenaGianluca ColussiNicola PassarielloLuca RinaldiFranco BertiGiuseppe FamularoTarsitani PatriziaRoberto CastelloMichela PasinoGian Paolo CedaMarcello Giuseppe MaggioSimonetta MorgantiAndrea ArtoniStefano Del GiaccoDavide FirinuFrancesca LosaGiovanni PaolettiGiuseppe MontaltoAnna LicataValentina MalerbaLasco AntoninoGiorgio BasileCatalano AntoninoLorenzo MalatinoBenedetta StancanelliValentina TerranovaSalvatore Di MarcaPatrizia MecocciCarmelinda RuggieroVirginia BoccardiTiziana MeschiFulvio LauretaniAndrea TicinesiPietro MinuzLuigi FondrieschiMario PirisiGian Paolo FraDaniele SolaMassimo PortaPiero RivaRoberto QuadriGiorgio ScanziCaterina MengoliStella ProviniLaura RicevutiEmilio SimeoneRosa ScurtiFabio TollosoRoberto TarquiniAlice ValorianiSilvia DolentiGiulia VanniniAlberto TedeschiLucia TrottaRiccardo VolpiPietro BocchiAlessandro VignaliSergio HarariChiara LonatiMara CattaneoRamirez Duque NievesMuela Molinero AlbertoAbad Requejo PedroLopez Pelaez VanessaTamargo LaraCorbella Viros XavierFormiga FrancescDiez Manglano JesusBejarano Tello EsperanzaDel Corral Behamonte EstherSevil Puras MariaManuel RomeroPinilla Llorente BlancaLopez Gonzalez-cobos CristinaVillalba Garcia M. VictoriaLopez SaezJuan BoscoSanz Baena SusanaArroyo Gallego MartaGonzalez Becerra ConcepcionFernandez Moyano AntonioMercedes Gomez HernandezManuel Poyato BorregoPacheco Cuadros RaquelPerez Rojas FlorenciaGarcia Olid BeatrizCarrascosa Garcia SaraGonzalez-cruz Cervellera AlfonsoPeinado Martinez MartaSara Carrascosa GarciaRuiz Cantero AlbertoAlbarracín Arraigosa AntonioGodoy Guerrero MontserratBarón Ramos Miguel ÁNgelMachin Jose ManuelNovo Veleiro IgnacioAlvela Suarez LucíaLopez AlfonsoRubal Bran DavidIñiguez Vazquez IriaRios Prego Monica

subject

Malemedicine.medical_specialtyPopulation ageingDeprescribing; Inappropriate prescription; Medication reconciliation; Multimorbidity; PolypharmacyPopulationSocio-culturale030204 cardiovascular system & hematology03 medical and health sciences0302 clinical medicineDeprescribingRisk Factors80 and overDeprescribing; Inappropriate prescription; Medication reconciliation; Multimorbidity; Polypharmacy; Internal Medicine; Emergency MedicineInternal MedicinemedicineDeprescribing Inappropriate prescription Medication reconciliation Multimorbidity PolypharmacyHumansMultimorbidityRegistries030212 general & internal medicineMedical prescriptionAdverse effecteducationAgedAged 80 and overPolypharmacyGeriatricseducation.field_of_studybusiness.industryMultimorbidityPatient DischargeHospitalizationDeprescribing; Inappropriate prescription; Medication reconciliation; Multimorbidity; Polypharmacy; Aged; Aged 80 and over; Female; Geriatrics; Hospitalization; Humans; Italy; Male; Multimorbidity; Patient Discharge; Registries; Risk Factors; PolypharmacyItalyGeriatricsFamily medicinePolypharmacyEmergency MedicineMedication reconciliationFemaleDeprescribingbusinessDeprescribing; Inappropriate prescription; Medication reconciliation; Multimorbidity; Polypharmacy;Inappropriate prescription

description

As a consequence of population aging, we have witnessed in internal medicine hospital wards a progressive shift from a population of in-patients relatively young and mainly affected by a single ailment to one of ever older and more and more complex patients with multiple chronic diseases, followed as out-patients by many different specialists with poor integration and inevitably treated with multiple medications. Polypharmacy (defined as the chronic intake of five or more drugs) is associated with increased risks of drug-drug interactions and related adverse effects, prescription and intake errors, poor compliance, re-hospitalization and mortality. With this background, the Italian Society of Internal Medicine chose to start in 2008 a prospective register called REPOSI (REgistro POliterapie SIMI, Società Italiana di Medicina Interna) in internal medicine and geriatric hospital wards. The country wide register is an ongoing observatory on multimorbidity and polypharmacy in the oldest old, with the goal to improve prescription appropriateness and, thus to avoid potentially inappropriate medications. The main findings of the register, that has accrued so far, 7005 older patients throughout a 10 year period, are summarized herewith, with special emphasis on the main patterns of poor prescription appropriateness and related risks of adverse events.

yearjournalcountryeditionlanguage
2018-08-31Internal and Emergency Medicine
https://doi.org/10.1007/s11739-018-1941-8