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RESEARCH PRODUCT

Tobacco and alcohol consumption after total laryngectomy and survival: A German multicenter prospective cohort study

Helge DankerFriedemann PabstJudith KeszteMartin EichlerMartin EichlerAlexandra MeyerJens OekenOrlando Guntinas-lichiusSusanne Singer

subject

medicine.medical_specialtyProportional hazards modelbusiness.industrymedicine.medical_treatmentHazard ratioConfidence intervalSurgeryLaryngectomy03 medical and health sciences0302 clinical medicineOtorhinolaryngology030220 oncology & carcinogenesisInternal medicineCohortmedicine030212 general & internal medicineRisk factorProspective cohort studybusinessCohort study

description

Background We examined the relation of tobacco and alcohol consumption after total laryngectomy with overall survival (OS). Methods Tobacco and alcohol consumption was assessed at 5 time points after total laryngectomy. Patients were followed up for survival until December 31, 2014. A multivariate Cox regression was fitted to test for differences in OS. Results Three hundred fifty-nine patients were included in this study. Compared to former smokers, never smokers had hazard ratios (HRs) of 0.88 (95% confidence intervals [CIs] = 0.50–1.59), and continuous smokers 1.31 (95% CI = 0.87–1.96). Constantly high alcohol consumption after total laryngectomy had an HR of 2.19 (95% CI = 1.30–3.67). Duration of smoking (HR = 1.00; 95% CI = 0.99–1.01) and last known status of alcohol consumption (HR = 1.00; 95% CI = 0.76–1.33) was not related to OS. Conclusion Patients who smoke after total laryngectomy have a 30% higher risk of dying than people who gave up smoking, and constant high alcohol consumption is also a strong risk factor for dying. © 2016 Wiley Periodicals, Inc. Head Neck, 2016

yearjournalcountryeditionlanguage
2016-04-04Head & Neck
https://doi.org/10.1002/hed.24436