6533b85dfe1ef96bd12bdcec
RESEARCH PRODUCT
Die Wirkung von Reserpin auf die Konzentration von Adrenalin und Noradrenalin im Katzenherz
Erich Muschollsubject
Pharmacologymedicine.medical_specialtyHeart pharmacologyEndocrinologyCATSChemistryInternal medicinePharmacology toxicologymedicineGeneral MedicinePostganglionic nerve fibresReserpinemedicine.drugdescription
1. Cats were given single injections of 1.8 mg/kg reserpine intraperitoneally. After a time interval of 18 hours the animals were killed. The concentration of adrenaline and noradrenaline in the right and left atria and ventricles was estimated by a method reported previously. 2. Reserpine caused a similar loss of catechol amines from all parts of the heart. The concentration of noradrenaline was reduced by 93–97%, the concentration of adrenaline by 59–79%. 3. These observations suggest that the adrenaline of the heart behaves differently from that of sympathetic ganglia or postganglionic nerve fibres after an injection of reserpine. In ganglia and nerve fibres the adrenaline concentration is not significantly affected by reserpine as previous work has shown.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1959-01-01 | Naunyn-Schmiedeberg's Archiv f�r Experimentelle Pathologie und Pharmakologie |