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RESEARCH PRODUCT

Lack of plasmic beta-endorphin response to a gastronomic meal in healthy humans.

Marian ApfelbaumFrédéric FumeronJ.c. MelchiorA. PetietD. RigaudM.-d. LaforestN. Colas-linhartMarc Fantino

subject

AdultBlood GlucoseMaleendocrine systemmedicine.medical_specialtyHungerAppetiteExperimental and Cognitive PsychologyPeptide hormoneBehavioral Neurosciencechemistry.chemical_compoundEatingInternal medicinemedicineHumansPalatabilityEndogenous opioidMealbusiness.industrydigestive oral and skin physiologybeta-EndorphinPentagastrinAffectEndocrinologychemistryBasal (medicine)TasteReceptors Opioidbeta-EndorphinOpiatebusinessArousalEnergy Intakehormones hormone substitutes and hormone antagonistsmedicine.drug

description

Abstract In order to study the relationship between the endogenous opiate system and food intake in man, plasma concentrations of beta-endorphin were measured in ten healthy subjects. Time course of beta-endorphinemia was compared under the following conditions: basal (fasting), after an injection of pentagastrin (6 μg/kg), or after a gastronomic meal. No changes in plasma beta-endorphin or ACTH concentrations were observed with pentagastrin nor after the meal, despite the combination of very high sensory pleasure with intake of a very large amount of food. It is concluded that blood beta-endorphin concentration is not a sensitive index of the effects of food intake on the endogenous opioid system in man.

yearjournalcountryeditionlanguage
1991-06-01Physiologybehavior
10.1016/0031-9384(91)90354-qhttps://pubmed.ncbi.nlm.nih.gov/1654572