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RESEARCH PRODUCT
The Erythrocytic Hypothesis of Brain Energy Crisis in Sporadic Alzheimer Disease: Possible Consequences and Supporting Evidence
Gubidat AlilovaLyudmila A. TikhonovaElena KosenkoCarmina MontoliuAmparo Uriossubject
Systemic diseaselcsh:MedicineBrain tissueDiseaseReview03 medical and health sciences0302 clinical medicinebrain energy crisismedicineDementiaerythrocytic hypothesis030304 developmental biology0303 health sciencesbusiness.industrylcsh:RNeurodegenerationGeneral Medicinemedicine.diseaserestoration of energy metabolismDrug developmentamyloid β peptidesEtiologyAlzheimer's diseasebusinessNeuroscienceAlzheimer’s disease030217 neurology & neurosurgeryred blood cellsdescription
Alzheimer’s disease (AD) is a fatal form of dementia of unknown etiology. Although amyloid plaque accumulation in the brain has been the subject of intensive research in disease pathogenesis and anti-amyloid drug development; the continued failures of the clinical trials suggest that amyloids are not a key cause of AD and new approaches to AD investigation and treatment are needed. We propose a new hypothesis of AD development based on metabolic abnormalities in circulating red blood cells (RBCs) that slow down oxygen release from RBCs into brain tissue which in turn leads to hypoxia-induced brain energy crisis; loss of neurons; and progressive atrophy preceding cognitive dysfunction. This review summarizes current evidence for the erythrocytic hypothesis of AD development and provides new insights into the causes of neurodegeneration offering an innovative way to diagnose and treat this systemic disease.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2020-01-12 | Journal of Clinical Medicine |