6533b85dfe1ef96bd12bdeed

RESEARCH PRODUCT

Molecular epidemiology and whole genome sequencing analysis of clinical Mycobacterium bovis from Ghana

Julian ParkhillDorothy Yeboah-manuSimon R. HarrisMireia CoscollaAkosua BaddooStephen Osei-wusuSamuel Acquah EkubanSebastien GagneuxSebastien GagneuxAudrey ForsonAbdallah Iddrisu YahayahAdwoa Asante-pokuClement LaryeaSamuel Yaw AboagyePrince AsareLeonor Sánchez-busóIsaac Darko OtchereAndries J. Van Tonder

subject

MaleBacterial Diseases0301 basic medicineBovine Tuberculosis in HumansHIV InfectionsComorbidityDrug resistanceGhanaBiochemistryMycobacterium BovisGeographical LocationsZoonosesMedicine and Health SciencesDisseminated diseaseBovine TuberculosisChildPathogenPhylogenyMolecular Epidemiology0303 health sciencesMycobacterium bovisMultidisciplinaryTransmission (medicine)QRAgricultureMiddle AgedLipids3. Good healthActinobacteriaInfectious DiseasesMedicineFemaleResearch ArticleAdultDNA BacterialLivestockTuberculosisAdolescentScience030106 microbiologyBiologyMycobacterium tuberculosisYoung Adult03 medical and health sciencesDrug Resistance BacterialmedicineAnimalsHumansTuberculosisTuberculosis PulmonaryAged030304 developmental biologyWhole genome sequencingWhole Genome SequencingBacteriaMolecular epidemiology030306 microbiologyOrganismsBiology and Life SciencesTropical DiseasesLipid MetabolismrpoBmedicine.diseasebiology.organism_classificationVirologyMetabolism030104 developmental biologyMutationPeople and PlacesAfricaCattleTuberculosis BovineMycobacterium Tuberculosis

description

[Background]: Bovine tuberculosis (bTB) caused by Mycobacterium bovis is a re-emerging problem in both livestock and humans. The association of some M. bovis strains with hyper-virulence, MDR-TB and disseminated disease makes it imperative to understand the biology of the pathogen.

10.1371/journal.pone.0209395https://edoc.unibas.ch/69764/